Alternative splicing is a developmental switch for hTERT expression
نویسندگان
چکیده
منابع مشابه
Developmental expression and alternative splicing of chick agrin RNA.
Agrin is a synaptic basal lamina protein that has been proposed to mediate motor neuron-induced clustering of acetylcholine receptors during development of the neuro-muscular junction. The chick ciliary ganglion is a parasympathetic ganglion that contains motor neurons that project to striated and smooth muscle targets in the eye. We have examined agrin gene expression in the chick ciliary gang...
متن کاملRole of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
متن کاملAlternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity
The activation of telomerase is one of the key events in the malignant transition of cells, and the expression of human telomerase reverse transcriptase (hTERT) is indispensable in the process of activating telomerase. The pre-mRNA alternative splicing of hTERT at the post-transcriptional level is one of the mechanisms for the regulation of telomerase activity. Shifts in splicing patterns occur...
متن کاملExpression Pattern of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase (hTERT) in Cancer Cell Lines Was not Associated with the Origin of the Cells
Telomerase and systems controlling their activity have been of great attention. There are controversies regarding the role of the alternative splicing forms of the human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase. Therefore, the correlation between telomerase enzyme activity, the abundance of alternatively spliced variants of hTERT and doubling time of a seri...
متن کاملNew Tools for Expression Alternative Splicing Validation
Alternative Splicing is one of the most important research targets in biology because it can explain the remarkably higher complexity of transcriptome and proteome of human and other metazoa with respect to their gene complement. The advent of DNA sequencing made the possibility to save the whole human genome in a ~3Gb database, that bioinformaticians can investigate by using suitable methods f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2021
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2021.03.033